Preheat oven to 375 degrees F and grease a glass 9x13 inch baking dish with cooking spray. Set aside.
In a large bowl, mix together chicken, vegetables, garlic powder, onion powder, paprika, basil, salt, pepper, and optional cayenne pepper until combined, then spread into an even layer in the prepared baking dish.
Drizzle evenly with melted butter, then set aside.
In the same bowl, whisk together bisquick, milk, and shredded cheese until combined, then pour over the chicken and vegetables; don’t stir and set aside.
In the same bowl, whisk together soup and broth until combined, then pour over the bisquick mixture; again, do not stir.
Bake in preheated oven, uncovered, for 45-60 minutes, or until the edges and top are golden brown and there’s only a slight jiggle in the center.
Allow to cool for 10 minutes before scooping and serving!