Preheat oven to 400 degrees F and grease a 9 inch pie dish with cooking spray. Set aside.
Heat a large non-stick skillet over medium heat, then once hot, add in beef, onion, Worcestershire sauce, and soy sauce.
Cook, breaking up the beef as you go, until the meat is no longer pink and the onions are tender.
Drain the excess grease, stir in mayo, mustard, ketchup, salt, pepper, garlic powder, onion powder, and pickles then taste and re-season, if desired.
Spread the beef mixture into an even layer in the prepared pie dish, sprinkle with cheese, then set aside.
In a large bowl, whisk together Bisquick, half-and-half, and eggs until *just* combined - don’t overmix, then pour evenly over the cheese - don’t mix.
Bake in preheated oven for 30 minutes or until the pie has cooked through; be sure to cover with foil if the top starts to brown too quickly.
Remove from oven, then let rest for 5 minutes before slicing and serving!
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